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A Meta-analysis of Mortality Factors in Patients with Klebsiella Pneumoniae Bloodstream Infection

Ashao Jia, Guangchao Yu
Frontiers in Science and Engineering, (2022), Vol.2, No.11, pp.44-53
Published: November 22, 2022
DOI: 10.54691/fse.v2i11.2977
PDF: Download Full Text PDF
Abstract

Objective: To systematically analyze the risk factors for bloodstream infections (BSI) of Klebsiella pneumoniae (KP) and its adverse prognosis (death), and provide theoretical basis for improving clinical prevention and control efficiency and reducing mortality. Methods: The literatures related to KP BSI risk factors and death risk factors were searched in CNKI, Wanfang, VIP, PubMed and Cochrane databases. Relevant literatures were screened according to inclusion and exclusion criteria, and the quality evaluation and data extraction were carried out for the finally included literatures. Meta-analysis was conducted by STATA12.0 software. Results: A total of 9 literatures were included with a total sample size of 2014, all of which were retrospective studies with NOS scores of 7-9.Meta analysis showed that: the history of hospitalization, history of ICU stay, high blood pressure, heart disease, kidney disease, lung disease, liver abscess, hypoalbuminemia, hemodialysis, mechanical ventilation, deep venipuncture, indwelling gastric tube, parenteral nutrition, placing a urinary catheter use radiotherapy/ chemotherapy, hormone and immune inhibitor use, antibiotics (beta lactam, carbon green alkene, quinolone, for ring element, cephalosporins) the use of the difference between groups was statistically significant (P < 0.05).Publication bias showed that ICU admission history, hypertension, and malignant tumors were biased. After the one-way study was adopted, ICU admission history and hypertension had no significant bias, which was accepted. Conclusion: the history of hospitalization, history of ICU stay, high blood pressure, heart disease, kidney disease, lung disease, liver abscess, hypoalbuminemia, hemodialysis, mechanical ventilation, deep venipuncture, indwelling gastric tube, parenteral nutrition, placing a urinary catheter use radiotherapy/ chemotherapy, hormone and immune inhibitor use, antibiotics (beta lactam, carbon green alkene, quinolone, for ring element, cephalosporins) the use of KP is the major risk factors of death in patients with bloodstream infections.

Keywords: Klebsiella Pneumoniae, Bloodstream Infection, Death Factors, Meta Analysis
APA Citation: Ashao Jia, Guangchao Yu (2022). A Meta-analysis of Mortality Factors in Patients with Klebsiella Pneumoniae Bloodstream Infection. Frontiers in Science and Engineering, 2(11), 44-53. https://doi.org/10.54691/fse.v2i11.2977

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