Preparation and Morphology Control of Hydroxyapatite by Aqueous Precipitation

Tingting Zhai; Yu Lin; Yunan Chen; Zhihong Lian

doi:10.54691/p46chn44

Preparation and Morphology Control of Hydroxyapatite by Aqueous Precipitation

Tingting Zhai, Yu Lin, Yunan Chen, Zhihong Lian

Scientific Journal of Technology, (2024), Vol.6, No.1, pp.37-41

Published: January 22, 2024

DOI: 10.54691/p46chn44

PDF: Download Full Text PDF

Abstract

Hydroxyapatite, with excellent biocompatibility, biological activity, and biological affinity, is the main inorganic component of human bones and teeth. It can promote bone tissue regeneration and has important applications in bone tissue engineering fields such as bone defect repair and bone replacement. In this study, calcium acetate solution and diammonium dihydrogen phosphate solution had been mixed to prepare calcium phosphate through aqueous precipitation reaction. The testing results of scanning electron microscopy and X-ray diffraction show that the morphology of the product can be controlled by changing the pH, the temperature, and the method of adding reactant solution dropwise. When the temperature of the reaction system is 20℃, plate-like calcium hydrogen phosphate is mainly obtained; block-like hydroxyapatite is obtained when the temperature rised to 40℃; and needle shaped hydroxyapatite is obtained at 60℃. The length and diameter of two-dimensional hydroxyapatite crystals become smaller when the temperature and the pH value of the reaction system increase.

Keywords: Hydroxyapatite; Precipitation Method; Crystal Morphology.

APA Citation: Tingting Zhai, Yu Lin, Yunan Chen, Zhihong Lian (2024). Preparation and Morphology Control of Hydroxyapatite by Aqueous Precipitation. Scientific Journal of Technology, 6(1), 37-41. https://doi.org/10.54691/p46chn44

References

QI J Q, Chen Y. Hydroxyapatite/polymer composite scaffolds in repairing bone defects: research progress[J]. Academic Journal of Naval Medical University, 2023, 44(11):1321-1327.
Aleksandra Szczes, Lucyna Holysz, Emil Chibowski. Synthesis of hydroxyapatite for biomedical applications. Advances in Colloid and Interface Science, 2017, 249: 321-330.
Guo L F, Zhang W G, Wang C Y. Synthesis of Nano Particle Hydroxyapatite and Crystallization Control[J]. Chinese Journal of Inorganic Chemistry, 2004, 20(3): 291-296.
Zhu Q X, ,Jiang W H, Wang H D, Shao C. Investigation on Preparation Factors for Fluorhydroxyapatite by an Aqueous Precipitation Method [J]. Journal of Inorganic Materials, 2011, 26(12): 1335-1339.
Satheesh Kumar Balu, Bargavi P. Chirtra S, et al. Morphological evaluation of HAp nanostructures and its shape-dependent protein adsorption study[J]. Materials Letters, 2023, 331:133491.
Xiao X L, Kong D Y, Zhang J S. Morphologically Controlled Synthesis of Hydroxyapatite at Mild Conditions[J]. Chinese Journal of Inorganic Chemistry, 2016, 32(2): 289-296.
Peng H, Wang L, Tian Y S, et al. Effect of different reaction temperatures and reactant sources on hydroxyapatite nanoparticles synthesized in a preparation process[J]. Journal of Beijing University of Chemical Technology (Natural Science), 2016, 43(1): 19-25.
Wang D P, Wang L, Huang W G. Effect of pH value on nanosized hydroxyapatite synthesized through precipitation process[J]. Journal of Tongji University (Natural Science), 2005, 33(01): 93-98.
Huang H Y, Yang M, Zhang C Z, et al. The effect of liquid-phase precipitation process conditions on hydroxyapatite powder [J]. Journal of Materials Research, 2012, 26(02): 187-190.