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Research Progress in Bone Defect Repair Based on Piezoelectric and Natural Polymeric Materials

Xiangyi Ning, Jianing Nie, Yubin Pang, Weiwei Fan, Peng Wang, Jiupeng Deng
World Scientific Research Journal, (2026), Vol.12, No.6, pp.19-30
Published: June 16, 2026
DOI: 10.6911/WSRJ.202606_12(6).0003
PDF: Download Full Text PDF
Abstract

Natural polymer materials have attracted considerable attention in bone tissue engineering and oral and maxillofacial bone defect repair because their structures are highly similar to the extracellular matrix (ECM) in the human body. However, single natural polymer materials usually have several limitations related to osteogenesis, including insufficient mechanical properties, difficulty in controlling the in vivo degradation rate, and limited three-dimensional structural stability.In recent years, researchers have combined piezoelectric materials with natural polymers to mimic the microelectrical signals generated by bone tissue under mechanical stimulation. Piezoelectric ceramics, such as barium titanate, potassium sodium niobate, and zinc oxide, as well as piezoelectric polymers such as poly-L-lactic acid, can generate microelectrical signals under mechanical force. These signals can promote osteoblast proliferation and differentiation, enhance mineral deposition in bone tissue, and ultimately contribute to bone defect repair.This review focuses on the current research progress of piezoelectric materials, natural polymer materials, and bone defect repair. It summarizes the characteristics, biological mechanisms, and application advances of different materials. This review aims to promote further research on natural polymer-based piezoelectric composites for bone defect repair and improve their translational potential for future clinical applications.

Keywords: Bone defect; piezoelectric material; natural polymer; silk fibroin; chitosan; bone tissue engineering.
APA Citation: Xiangyi Ning, Jianing Nie, Yubin Pang, Weiwei Fan, Peng Wang, Jiupeng Deng (2026). Research Progress in Bone Defect Repair Based on Piezoelectric and Natural Polymeric Materials. World Scientific Research Journal, 12(6), 19-30. https://doi.org/10.6911/WSRJ.202606_12(6).0003

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